Alternative Medicine and Cancer
Coley's Toxins were once widely used within conventional medicine. It, or quite likely a toned-down version of it , is now only offered by some alternative clinics.
I learnt about Coley's toxins in medical school! We were told how doctors noticed that cancers occasionally went into remission after a major febrile (feverish) episode. Coley used the toxins of certain bacteria to mimic such a febrile response and found cancers sometimes seemed to respond to this treatment.
Coley developed his treatment in the late 19th century but controversy concerning it persisted for over half a century. A controlled trial was finally performed and published in 1962. To some extent this resolved the matter in favour of Coley's toxins,. although a single trial cannot be regarded as the final word.
I sent this (slightly edited) summary of the paper to a newsgroup.
" Judging from the references in this paper this is the only controlled trial
that was ever done on Coley's
toxins, even though they had already been in use for a remarkable seventy
years. It appears that some were claiming results which others could not
replicate, but that some effect was being also reported in animal studies of
Nine out of 34 patients in the treated group appeared to show
objective benefits (i.e. cancer remission) , but none at all in the untreated group. One patient with a recurrent giant cell tumour of
the thyroid had a complete response and was free of cancer four years
later. Eight other patients had partial or brief remissions but two of
these were lost to follow up very shortly afterwards (one died of accident).
The rest died of their cancers or with their cancers in from three months to
There is no certainty that what is offered as Coley's toxins by some alternative clinics is comparable.."
Despite this study the method died out within conventional circles. Why? I suspect that by this time more reliable results were being observed with some types of cancer from the emerging chemotherapies. They were simpler to use, they didn't have to make the patient sick nearly all the time, and they did not require constant medical attention. Some kinds of cancer were also being regularly brought into remission and occasionally cured for the first time.
Also Warburg had recently shown that cancer cells tend to use anaerobic rather than aerobic metabolic pathways. This is now known to not be crucial to their survival -- cancer cells grow quite well in tissue culture when exposed to the ample oxygen in room air, and even hyperbaric oxygen fails to stop cancer (putting hydrogen peroxide with its much weaker ability to raise oxygen levels in the "highly implausible" category of alternative treatments) . Nevertheless this discovery was hailed at the time as a major advance, being the very first biochemical difference ever to be demonstrated between cancer cells and normal cells.
I suspect these developments. along with the recent spectacular successes of antibiotics against bacterial infections, induced a climate of optimism that left little enthusiasm for such a now well-tried but fickle treatment method as Coley's toxins. There is no good reason that I can see why it might not have persisted as something to try as a rather desperate last resort.
Interestingly, some conventional chemotherapeutic agents are bacterial toxins (adriamycin, bleomycin). .