MR Spectroscopy Case Study
Anaplastic Astrocytoma - grade 2
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March 2nd 2001
| The
Adelaide MR Web Site
MR Spectroscopy Case Study Anaplastic Astrocytoma - grade 2 |
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| Prepared by Greg Brown
Royal Adelaide Hospital North Terrace Adelaide South Australia 5000
March 2nd 2001 |
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Images and Spectra obtained on a Siemens VISION 1.5T using Numairs VB33E
software. Images and Spectra converted to JPEG files using eFilm.
| Presentation | Imaging | MRS Technique | MRS Results | Histopathology | Discussion |
| CT 9/97 | Two focal hypodense lesions in the left cerebral hemisphere (temporal and parietal). Contrast used but no comment on enhancement or oedema |
| MRI 10/97 | Multiple high signal lesions in both cerebral hemispheres (right frontal, both temporal lobes) ? drug induced vasculitis |
| MRI 7/98 | Lesion increasing in size and continuity. Some mass effect. Appearances suggest multifocal glioma. |
| MRI 11/98 | patient deteriorating. lesions in left basal ganglia and left frontal lobe increasing. No significant contrast enhancement. |
| MRI August 99 & December 99 |
showed no change in lesions and gave no definitive diagnosis |
| MRI 25/8/2000 | Mild progression since last exam. Cortical and white matter changes in frontal lobe and insular cortex. Cystic components with minor mass effect. "Spectroscopy performed on the left temporal lobe. This demonstrates a reduction in NAA and an increase in Choline consistent with infiltrating neoplasm." |
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Large water signal and poor automatic phasing, but the spectral resolution
of Cho and Cr is adequate and the options available in Siemens MRS allowed
for a good spectrum.
Obviously increased Choline and reduced NAA with no Lactate.
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